Primary Medical Therapy for Acromegaly
نویسندگان
چکیده
منابع مشابه
Medical Therapy of Acromegaly
This paper outlines the present status of medical therapy of acromegaly. Indications for permanent postoperative treatment, postirradiation treamtent to bridge the interval until remission as well as primary medical therapy are elaborated. Therapeutic efficacy of the different available drugs-somatostatin receptor ligands (SRLs), dopamine agonists, and the GH antagonist Pegvisomant-is discussed...
متن کاملOctreotide as primary therapy for acromegaly.
The effects of octreotide (up to 5 yr) as primary treatment in 26 patients with acromegaly were compared with those in 81 patients with acromegaly who received octreotide as secondary or adjunctive therapy after previous surgery and/or pituitary radiation. These patients were part of a multicenter study that took place between 1989-1995. The study was divided into 3 phases beginning with a 1-mo...
متن کاملA critical analysis of pituitary tumor shrinkage during primary medical therapy in acromegaly.
CONTEXT Somatostatin analogs have been successfully used to treat patients with GH-secreting pituitary adenomas because they are safe, effective, and usually well tolerated. The results of studies evaluating acromegaly treatment with the somatostatin receptor ligands (SRLs), octreotide and lanreotide, have supported the use of these agents for primary medical therapy before or as an alternative...
متن کاملCurative Result with Primary Medical Therapy in an Elderly Acromegaly Patient
In acromegaly, transsphenoidal hypophysectomy is the primary treatment of choice. Medical treatment is performed on patients uncontrollable with surgery. Indications for primary medical treatment or medical treatment prior to surgery are limited to patients with macroadenoma with high risk for surgery due to cardiac and respiratory problems. Medical treatment is not applied on patients with mic...
متن کاملAcromegaly: a new therapy.
BACKGROUND The treatment of acromegaly can be challenging. Despite a multimodality approach (surgery,radiation, dopamine agonists, somatostatin analogs), many patients do not achieve normalization of serum insulin-like growth factor I (IGF-I) concentrations. METHODS The author discusses the characteristics and indications of pegvisomant therapy for patients with acromegaly and compares the us...
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ژورنال
عنوان ژورنال: Journal of Clinical Endocrinology & Metabolism
سال: 1998
ISSN: 0021-972X
DOI: 10.1210/jc.83.9.3031